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Erratum to: The extracellular Leucine-Rich Repeat superfamily; a comparative survey and analysis of evolutionary relationships and expression patterns
BMC Genomics volume 10, Article number: 230 (2009)
Abstract
Correction to Dolan J, Walshe K, Alsbury S, Hokamp K, O'Keeffe S, Okafuji T, Miller SF, Tear G, Mitchell KJ: The extracellular leucine-rich repeat superfamily; a comparative survey and analysis of evolutionary relationships and expression patterns. BMC Genomics 2007, 8:320.
Correction
In our original article [1] a mistake was made in Figure Four in the depiction of the structure of the Drosophila gene CG8561, now called Als or dAls (Drosophila acid-labile subunit). The correct structure is shown here in Figure 1, based on a newly-available and slightly extended sequence of CG8561 from the Ensembl database (FBpp0086669). This gene should have been shown to encode a secreted protein with 29 LRR domains, an N-terminal LRR-NT and a C-terminal LRR-CT domain, based on the LRRscan programme output. Use of the new sequence does not alter the clustering relationships of the CG8561 protein, shown in Figure Two and in Additional Files Three-Five of the original paper. We note that these data, derived from TribeMCL, which simultaneously takes all pairwise relationships across all members of the proteomes of the four species used into account, do not provide strong support for direct one-to-one orthology between CG8561 and mammalian Igfals.
The reassignment of structure also changes the figures in Table Two (shown here as Table 1). There should be 11 type I transmembrane and 4 secreted proteins in flies in the LRR-Tollkin subgroup.
References
Dolan J, Walshe K, Alsbury S, Hokamp K, O'Keeffe S, Okafuji T, Miller SF, Tear G, Mitchell KJ: The extracellular leucine-rich repeat superfamily; a comparative survey and analysis of evolutionary relationships and expression patterns. BMC Genomics. 2007, 8: 320-10.1186/1471-2164-8-320.
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The online version of the original article can be found at 10.1186/1471-2164-8-320
Jackie Dolan, Karen Walshe contributed equally to this work.
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Dolan, J., Walshe, K., Alsbury, S. et al. Erratum to: The extracellular Leucine-Rich Repeat superfamily; a comparative survey and analysis of evolutionary relationships and expression patterns. BMC Genomics 10, 230 (2009). https://doi.org/10.1186/1471-2164-10-230
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DOI: https://doi.org/10.1186/1471-2164-10-230