Figure 5
Correspondence analysis of relative expression and transcription factor binding sites of human orthologous imprintedgenes. (a) Human orthologous imprinted gene expression for all tissues as well as p-values for the 107 most prevalent TFBSs were analysed by multiplying the respective matrices. In this figure, the first (x axis) and second (y axis) components of correspondence analysis are shown. TFBS names are indicated by black spots, tissues in red triangles. (b) Zoom in the 3rd quadrant of figure 5a. Placenta tissue is highlighted in red. A red dashed line marks the vector that defines the location of human placenta tissue in the correspondence plot. TFBS that show the smallest angle, i.e. highest association to human placenta were investigated for their relative expression in human placenta. A red arrow marks up-, downregulation compared to cellular background, equality signs stands for approximately expressed as cellular background and nr stands for not represented on the array. (c) Zoom for the 2nd quadrant of figure 5 a. Pituitary, ovary and adrenal gland tissues are highlighted in red. A red dashed line marks the vector that defines the location of the three human tissues in the correspondence plot. TFBS that show the smallest angle, i.e. highest association to the three tissues were investigated for their relative expression in the same tissue. Caption is the same as in figure 5 b but for MRF2 the upregulation arrow and a star stands for the observation that MRF2 was found strongly upregulated in pituitary and ovary tissue but showed only slight upregulation in adrenal gland tissue.