Functional annotation of the human retinal pigment epithelium transcriptome

BMC Genomics

Table 5 Expression levels and interindividual differences of currently known macular disease genes with RPE expression[26].

gene symbol	Genbank accession	mean intensity μ_int (perc)		CV (perc)
high interindividual variation (CV > 10 ^th perc)
CFB	NM_001710	10,382	(94)	215	(99)
C3	NM_000064	9,910	(94)	145	(98)
FBLN5	NM_006329	2,823	(76)	136	(98)
PRPH2	NM_000322	32,204	(98)	86	(93)
GUCA1B	NM_002098	2,329	(72)	83	(93)
CST3	NM_000099	338	(26)	79	(92)
CFH	NM_000186	8,508	(92)	77	(91)
TIMP3	NM_000362	7,209	(91)	73	(90)
intermediate interindividual variation (CV 10 ^th – 90 ^th perc)
C2	NM_000063	1,689	(65)	71	(90)
BEST1	NM_004183	132,611	(99)	58	(84)
HTRA1	NM_002775	45,420	(99)	47	(74)
EFEMP1	NM_004105	20,292	(97)	44	(70)
C1QTNF5	NM_015645	23,226	(98)	40	(64)
TLR4	NM_003266	225	(45)	38	(60)
low interindividual variation (CV < 90 ^th perc)
none	-	-		-

Data are grouped by coefficient of variation (CV) in descending order into three groups, high CV (> 90^th percentile, CV > 72), intermediate (CV 10^th – 90^th percentile) and low CV (< 10^th percentile, CV < 19). Perc: percentile.

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