A network-based integrative approach to prioritize reliable hits from multiple genome-wide RNAi screens in Drosophila

Table 2 The overlap between KEGG pathway genes and hits/nonhits in the corresponding RNAi screen.

KEGG pathway (#genes)	All hits	Experimentally validated hits	Top-ranked hits	All nonhits	Top-ranked nonhits (RR > 0.9)	Top-ranked nonhits (RR > 0.8)
Hh signaling pathway (23)	9	6	9	14	7	10
Wnt signaling pathway (65)	9	8	9	56	32	48

Each cell represents the overlap between KEGG pathway genes (rows) and all, or subsets of, hits/nonhits in the corresponding RNAi screen (columns). The hits/nonhits were ranked by NePhe score. The top-ranked hits (column 3) are of the same size as the experimentally validated hits (column 2).

ISSN: 1471-2164