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Table 7 Overlapping transcripts between Btk-/- B-cells and Itk-/- T-cells

From: Transcriptional signatures of Itk-deficient CD3+, CD4+ and CD8+ T-cells

U74Av2

MOE 430 2.0

Gene Symbol, Gene Title

Fold change Btk-/-/Itk-/-

102330_at

1418204_s_at

Aif1, allograft inflammatory factor 1

7.47/2.28

95546_g_at

1419519_at

Igf1, insulin-like growth factor 1

6.5/2.46

103226_at

1450430_at

Mrc1, mannose receptor, C type 1

5.42/6.06

95597_at

1423414_at

Ptgs1, prostaglandin-endoperoxide synthase 1

4.68/2.43 **

95597_at

1436448_a_at

Ptgs1, prostaglandin-endoperoxide synthase 1

4.68/2.19 **

96020_at

1417063_at

C1qb, complement component 1, q subcomponent, beta polypeptide

4.57/6.6 ***

96020_at

1434366_x_at

C1qb, complement component 1, q subcomponent, beta polypeptide

4.57/5.87 ***

96020_at

1437726_x_at

C1qb, complement component 1, q subcomponent, beta polypeptide

4.57/4.46 ***

104354_at

1419873_s_at

Csf1r, colony stimulating factor 1 receptor

4.4/3.96 **

104354_at

1423593_a_at

Csf1r, colony stimulating factor 1 receptor

4.4/2.95 **

103736_at

1448005_at

Sash1, SAM and SH3 domain containing 1

3.97/6.79

103454_at

1418555_x_at

Spic, Spi-C transcription factor (Spi-1/PU.1 related)

3.93/3.75 *

103454_at

1449134_s_at

Spic, Spi-C transcription factor (Spi-1/PU.1 related)

3.93/8.5 *

92877_at

1415871_at

Tgfbi, transforming growth factor, beta induced

3.9/3.46 ***

92877_at

1437463_x_at

Tgfbi, transforming growth factor, beta induced

3.9/5.04 ***

92877_at

1448123_s_at

Tgfbi, transforming growth factor, beta induced

3.9/4.52 ***

92877_at

1456250_x_at

Tgfbi, transforming growth factor, beta induced

3.9/4.6 ***

92223_at

1449401_at

C1qc, complement component 1, q subcomponent, C chain

3.73/5.47

92558_at

1448162_at

Vcam1, vascular cell adhesion molecule 1

3.63/5.62

102065_at

1418243_at

Fcna, ficolin A

3.6/5.27

103070_at

1416985_at

Sirpa, signal-regulatory protein alpha

3.42/3.58

102860_at

1424923_at

Serpina3g, serine (or cysteine) peptidase inhibitor, clade A, member 3G

3.05/2.08 ***

99476_at

1453931_at

Col14a1, collagen, type XIV, alpha 1

2.95/(-)2.51

93013_at

1422537_a_at

Id2, inhibitor of DNA binding 2

2.77/2.03 **

102293_at

1421303_at

Ikzf1, IKAROS family zinc finger 1

(-)2.7/(-)2.2

99413_at

1419610_at

Ccr1, chemokine (C-C motif) receptor 1

(-)4.13/2.62 *

  1. The down-regulated transcripts are shown with "(-)"
  2. * Denotes significant changes in Itk-/- T-cells. * p ≤ 0.05 ** p ≤ 0.01 *** p ≤ 0.001