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Figure 1 | BMC Genomics

Figure 1

From: Cytokine-dependent and–independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling

Figure 1

Differential gene expression in T. cruzi -infected HFF, HMVEC and VSMC at 24 hours post-infection. A. Heat map of genes modulated during T. cruzi infection in each cell line identified by hybridization to HG_U133 2.0 arrays and analyzed with Rosetta Resolver. Genes modulated (≥ 2-fold, p < 0.01) in at least one of the three cell types are shown. B. Venn diagrams comparing up or downregulated genes (≥ 2-fold, p < 0.01) and GO functions (p < 0.05) in each cell type. C. qPCR analysis of the expression of interferon beta (IFN-β) mRNA normalized to GAPDH. D. Canonical pathways identified by Inguenuity Pathway Analysis™ software as significantly altered (p < 0.05) following T. cruzi infection of HFF, HMVEC and VSMC.

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BMC Genomics

ISSN: 1471-2164

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