Skip to main content

Table 2 Cytokine-independent biological functions modulated during T. cruzi infection.

From: Cytokine-dependent and–independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling

 

HFF

p-value

HFF

# genes

HMVEC

p-value

HMVEC

# genes

VSMC

p-value

VSMC

# genes*

UPREGULATED

GO CATEGORY

      

GO:9611: response to wounding

9.88E-09

29

9.25E-05

17

2.18E-05

17

GO:6955: immune response

1.02E-06

40

8.60E-05

27

2.01E-32

64

GO:42127: regulation of cell proliferation

1.76E-06

24

4.50E-04

15

4.37E-04

14

GO:6950: response to stress

1.45E-04

44

4.23E-05

35

6.12E-13

48

GO:6915: apoptosis

8.56E-03

24

1.38E-04

23

3.06E-03

18

DOWNREGULATED

GO CATEGORY

      

GO:7049: cell cycle

1.08E-05

78

2.03E-05

77

- -

- -

GO:6412: protein biosynthesis

1.51E-02

48

2.57E-02

47

- -

- -

  1. Shown are selected GO functions modulated (p < 0.05, overlap ≥ 5 genes) in a cytokine-independent fashion 24 hours after T. cruzi infection.* Transwell data was not available for VSMC.