Figure 5

Correlations between eGSA and IGA. (A) and (B), Scatter plots of GS significance ordered by eGSA (y-axis) and IGA (x-axis). Each circle represents one GS, and green triangles represent missed GSs in IGA. The color represents the percentage of up-regulated REs in a GS (RE_{up in GS}/RE_{total in GS}). Most GSs in Sts are correlated and aligned on the diagonal line. In Sve, the high- and low-rank GSs are also correlated but many GSs appear inconsistent (in 2^nd and 4^th quadrant). Their gene changes of two extremely inconsistent GSs, which are indicated by red and blue arrows, are further shown in (C) and (D). In these heatmaps, each row represents one gene in a GS while each column represents a tissue sample. The first column is the up-DEGs detected by IGA (shown in red). The event panel is REs detected by eGSA (red: up-REs; green: down-REs), while the signal panel is the standardized (mean = 0, SD = 0.5) microarray signals of all samples. The signal level is presented by the color scale (red: up-regulation; green: down).