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Figure 1 | BMC Genomics

Figure 1

From: Epistatic interactions modulate the evolution of mammalian mitochondrial respiratory complex components

Figure 1

Molecular mechanism of compensation at COI. (A) Three-dimensional model of human cytochrome oxidase c complex showing Leu195 and Leu196 positions in COI. (B) Detailed view of the wild-type background (195Leu-196Leu) showing side-chain bonding involving Ser187 (α-helix V) and Leu248 (α-helix VI). (C) Deleterious background (Leu195-Ile196) revealing the absence the H-bonding between α-helices V and VI. (D) Compensated background (Ile195-Ile196) establishing a novel H-bond involving Ser198 (α-helix V) and Phe238 (α-helix VI). (E) Transmembrane structure of the human wild-type COI showing the mutation position (red), the interchain connection in the wild-type background (orange) and the new interaction in the compensated background (green).

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BMC Genomics

ISSN: 1471-2164

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