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Figure 4 | BMC Genomics

Figure 4

From: Epistatic interactions modulate the evolution of mammalian mitochondrial respiratory complex components

Figure 4

Mitonuclear interaction between CYB and CYT1. (A) Human model showing structural proximity between CYB (grey) and CYT1 (yellow). (B) Structure of the wild-type background illustrating H-bond salt bridges across CYB/CYT1 interfaces (CYB-Asp248/CYT1-Arg496 and CYB-Asp254/CYT1-His499). (C) Structure of the deleterious background (CYB-Ser251). (D), (E) and (F) Structure of the compensated backgrounds (CYB-Pro258, CYB-Ser263 and CYB-Pro258-Ser263, respectively). A synopsis of the CYB/CYT1 salt bridge bonding patterns for all of the backgrounds is provided below the structures.

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BMC Genomics

ISSN: 1471-2164

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