Figure 4

An example of combined analysis of three identified regulatory modules. Schema showing the relationships among module 4, 27, and 28 in Table 2. miRNAs are in red, and mRNA targets are in turquoise (miR-215), or in yellow (miR-215 and miR-16), or in green (miR-16). B. Combined overview of three modules, including miR-215, miR-16, and 86 miR-215 targets and 191 miR-16 targets (21 targets in common). C. An overview of the network expanded from B, by adding protein interaction partners of targets (black dots). Lines indicate protein interaction or miRNA-mRNA regulation. D. A sub-network in (C). Shown are genes in significantly enriched (p-value < 0.01), and HCV associated (manually selected based on literatures) KEGG pathways, including Cell cycle, Apoptosis, P53, MAPK, Insulin, Focal adhesion, Jak-Stat, TGF-beta, Toll-like. Each pathway had at least 10 member genes, including 2 or more predicted targets in (C).