Figure 6

SP1 acts as a cofactor for promoter proximal hERα sites. Ranks of the induction scores are shown as boxplots in function of the number of promoter proximal (± 5 kbp around the TSS) ChIP sites with and without SP1 sites. The presence of SP1 motifs underlying promoter proximal ChIP sites increases the induction rank. Ranks are computed as in Fig. 5 and SP1 motifs are assigned to a ChIP site if the occupancy is greater than 0.5 (Cf. Methods). Significance is assessed by Wilcoxon rank sum test.