Table 2 Differentially expressed genes involved in cholesterol homeostasis in mouse liver after TCPOBOP treatment
From: Effect of CAR activation on selected metabolic pathways in normal and hyperlipidemic mouse livers
TCPOBOP + normal chow diet | Vehicle + cholesterol diet | TCPOBOP + cholesterol diet | |||||
|---|---|---|---|---|---|---|---|
Gene Symbol | Gene Description | Log2 ratio | p-value | Log2 ratio | p-value | Log2 ratio | p-value |
Cholesterol biosynthesis | |||||||
Sc4mol | Sterol-C4-methyl oxidase-like | nc | nc | -2.50 | 0.000 | 1.85 | 0.001 |
Cyp51 | Cytochrome P450, 51a1 | nc | nc | -1.86 | 0.001 | 1.27 | 0.008 |
Hmgcs1 | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 | nc | nc | -1.79 | 0.001 | 1.20 | 0.015 |
Fdps | Farnesyl diphosphate synthase 1 | nc | nc | -1.73 | 0.001 | 0.99 | 0.026 |
Fdft1 | Farnesyl diphosphate farnesyl transferase 1, Squalene synthase | nc | nc | -1.69 | 0.000 | 1.08 | 0.006 |
Nsdhl | NAD(P) dependent steroid dehydrogenase-like | nc | nc | -1.35 | 0.004 | 0.99 | 0.033 |
Lss | Lanosterol synthase | 0.60 | 0.033 | -1.31 | 0.000 | 0.81 | 0.012 |
Mvd | Mevalonate (diphospho) decarboxylase | nc | nc | -1.27 | 0.002 | 0.88 | 0.017 |
Mvk | Mevalonate kinase | nc | nc | -1.18 | 0.001 | 0.86 | 0.010 |
Hmgcr | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase | 0.99 | 0.001 | -1.14 | 0.001 | 1.09 | 0.008 |
Sqle | Squalene epoxidase | 0.49 | 0.014 | -1.11 | 0.014 | nc | nc |
Dhcr24 | 24-dehydrocholesterol reductase | nc | nc | -0.57 | 0.019 | 0.54 | 0.018 |
Dhcr7 | 7-dehydrocholesterol reductase | nc | nc | -0.36 | 0.049 | nc | nc |
Idi1 | Isopentenyl-diphosphate delta isomerase | nc | nc | 0.39 | 0.003 | nc | nc |
Sc5d | Sterol-C5-desaturase homolog | 0.36 | 0.029 | nc | nc | nc | nc |
SREBP signaling pathway | |||||||
Insig1 | Insulin induced gene 1 | 0.82 | 0.000 | nc | nc | nc | nc |
Mbtps1 | Membrane-bound transcription factor peptidase, site 1 | 1.72 | 0.000 | nc | nc | 2.06 | 0.003 |
Insig2 | Insulin induced gene 2 | 1.94 | 0.000 | 0.25 | 0.038 | 1.24 | 0.000 |
Bile acid synthesis | |||||||
Cyp8b1 | Cytochrome P450, 8b1 | -2.16 | 0.000 | nc | nc | -0.67 | 0.036 |
Cyp7b1 | Cytochrome P450, 7b1 | 0.21 | 0.014 | nc | nc | nc | nc |
Cyp27a1 | Cytochrome P450, 27a1 | 0.73 | 0.000 | nc | nc | 0.46 | 0.028 |
Cyp39a1 | Cytochrome P450, 39a1 | 1.06 | 0.000 | nc | nc | 0.91 | 0.000 |
Lipid transport | |||||||
Apoa5 | Apolipoprotein A-V | -0.57 | 0.013 | nc | nc | -0.45 | 0.039 |
Apoe | Apolipoprotein E | -0.38 | 0.019 | nc | nc | -0.46 | 0.022 |
Ldlr | Low density lipoprotein receptor | 0.32 | 0.017 | -0.38 | 0.037 | 0.42 | 0.039 |
Apoa4 | Apolipoprotein A-IV | 2.23 | 0.000 | 1.09 | 0.000 | 1.00 | 0.001 |
Transporters | |||||||
Abca1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.39 | 0.024 | 0.18 | 0.040 | -0.38 | 0.015 |
Abcb11 | ATP-binding cassette, sub-family B (MDR/TAP), member 11 | 0.46 | 0.001 | 0.68 | 0.000 | nc | nc |
Abcc2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | 0.92 | 0.000 | nc | nc | 0.89 | 0.000 |
Slco1a4 | Solute carrier organic anion transporter family, member 1a4 | 1.04 | 0.000 | -0.98 | 0.000 | 1.66 | 0.000 |
Abcc3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | 1.29 | 0.000 | -0.76 | 0.003 | 2.06 | 0.000 |
Abcg8 | ATP-binding cassette, sub-family G (WHITE), member 8 | nc | nc | nc | nc | -1.02 | 0.006 |
Abcg5 | ATP-binding cassette, sub-family G (WHITE), member 5 | nc | nc | nc | nc | -0.87 | 0.008 |
Slco2b1 | Solute carrier organic anion transporter family, member 2b1 | -0.40 | 0.001 | 0.25 | 0.009 | nc | nc |
Other | |||||||
Scarb1 | Scavenger receptor class B, member 1 | -0.87 | 0.000 | 0.31 | 0.003 | -0.88 | 0.000 |
Acat2 | Acetyl-Coenzyme A acetyltransferase 2 | -0.31 | 0.010 | nc | nc | -0.33 | 0.019 |
Lip1 | Lysosomal acid lipase 1 | 0.49 | 0.000 | 0.38 | 0.002 | 0.28 | 0.043 |
Saa2 | Serum amyloid A 2 | -3.60 | 0.000 | nc | nc | -3.28 | 0.001 |
Saa1 | Serum amyloid A 1 | -3.52 | 0.000 | nc | nc | -3.22 | 0.001 |
Saa3 | Serum amyloid A 3 | -3.39 | 0.000 | nc | nc | -2.87 | 0.001 |