Effect of CAR activation on selected metabolic pathways in normal and hyperlipidemic mouse livers

Režen, Tadeja; Tamasi, Viola; Lövgren-Sandblom, Anita; Björkhem, Ingemar; Meyer, Urs A; Rozman, Damjana

doi:10.1186/1471-2164-10-384

BMC Genomics

Table 4 Differentially expressed genes involved in glucose and triglyceride metabolism in mouse liver after TCPOBOP treatment

From: Effect of CAR activation on selected metabolic pathways in normal and hyperlipidemic mouse livers

		TCPOBOP + normal chow diet		Vehicle + cholesterol diet		TCPOBOP + cholesterol diet
Gene Symbol	Gene Description	Log₂ ratio	p-value	Log₂ ratio	p-value	Log₂ ratio	p-value
Carbohydrate metabolism
Pck1	Phosphoenolpyruvate carboxykinase 1, cytosolic	-0.47	0.042	nc	nc	-0.39	0.039
Pdhb	Pyruvate dehydrogenase (lipoamide) beta	0.61	0.000	0.33	0.005	0.43	0.014
G6Pase	Glucose-6-phosphatase catalytic	nc	nc	1.00	0.005	-1.26	0.000
Gapdh	Glyceraldehyde-3-phosphate dehydrogenase	nc	nc	0.49	0.016	nc	nc
Fatty acid metabolism
Cpt1a	Carnitine palmitoyltransferase 1a, liver	-0.81	0.000	nc	nc	-0.38	0.004
Hmgcl	3-hydroxy-3-methylglutaryl-Coenzyme A lyase	0.31	0.008	-0.53	0.001	0.64	0.003
Fasn	Fatty acid synthase	0.58	0.007	nc	nc	nc	nc
Scd1	Stearoyl-Coenzyme A desaturase 1	nc	nc	1.40	0.004	-1.32	0.018
Cyp4f14	Cytochrome P450, 4f14	nc	nc	0.98	0.000	-0.72	0.000
Transcription regulators
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	-1.17	0.000	nc	nc	-0.99	0.000
Sirt1	Sirtuin 1, silent mating type information regulation 2, homolog 1	-0.40	0.010	nc	nc	nc	nc
Foxa2	Forkhead box A2	-0.22	0.049	nc	nc	nc	nc
Mlxipl	MLX interacting protein-like, old Wbscr14 or Chrebp	0.94	0.000	1.05	0.000	0.32	0.047
Crem	CAMP responsive element modulator	nc	nc	0.35	0.002	-0.35	0.016
Ppara	Peroxisome proliferator activated receptor alpha	-0.84	0.000	0.53	0.035	-0.93	0.000
Pparg	Peroxisome proliferator activated receptor gamma	-0.83	0.005	nc	nc	nc	nc
Transporters
Slc2a4	Solute carrier family 2 (facilitated glucose transporter), member 4	-0.43	0.000	nc	nc	nc	nc
Slc2a1	Solute carrier family 2 (facilitated glucose transporter), member 1	0.37	0.001	nc	nc	0.32	0.011
Cell signaling
Ppp1r3c	Protein phosphatase 1, regulatory (inhibitor) subunit 3C	-3.47	0.000	-0.39	0.015	-2.64	0.000
Igf1	Insulin-like growth factor 1	-1.08	0.000	0.69	0.000	-1.37	0.000
Adipor2	Adiponectin receptor 2	-0.85	0.000	nc	nc	-0.80	0.001

Differentially expressed genes involved in glucose and triglyceride metabolism in mouse liver after TCPOBOP treatment or cholesterol diet as detected by the Steroltalk microarray. Data represent log₂ ratios of TCPOBOP treated versus vehicle treated on the same diet (standard or cholesterol) and vehicle treated group on cholesterol diet versus standard diet. Six animals per group were used and p-value was calculated using t-test as implemented in BRB-Array Tools. GeneBank accession numbers and are available in Additional file 1. nc – no change.

Back to article page

ISSN: 1471-2164

Contact us

Submission enquiries: bmcgenomics@biomedcentral.com
General enquiries: ORSupport@springernature.com