Table 3 Ingenuity analysis of the genes targeted by top eleven screened miRNAs
From: Identification and characterization of miRNAs expressed in the bovine ovary
miRNAs | Functions and disease categories enriched with the selected miRNA targets | Canonical Pathways enriched with the selected miRNA targets |
|---|---|---|
Let-7b | Tissue morphology, cellular growth and proliferation, endocrine system disorders | IGF-1 signaling, hepatic fibrosis/hepatic stellate cell activation |
mir-15b | cell death, connective tissue development and function, cell cycle | p53 signaling, PPARα/RXR activation |
mir-18a | Cell cycles, cellular function, endocrine system development | Cell cycle: G1/S checkpoint regulation, TGF-β signaling |
mir-29a | Reproductive system development and function, organ development, endocrine system development | Ephrin receptor signaling Aminophosphonate metabolism |
mir-101 | Endocrine system development, lipid metabolism, small molecule biochemistry | C21-steroid hormone metabolism, Androgen and estrogen metabolism |
mir-125b | Inflammatory response, cell cycle, cellular function and maintenance | LPS/IL-1 Mediated inhibition of RXR function, LXR/RXR activation |
mir-126 | Cellular movement, Endocrine system disorders, cell mediated immune response | Pro-apoptosis, PXR/PXR activation |
mir-143 | Cellular growth and proliferation, DNA replication, recombination and repair, gene expression | G1/S transition of the cell cycle, p53 signaling |
mir-145 | Reproductive system diseases, reproductive system development and function, cell death | BMP signaling pathway, VEGF signaling |
mir-199a | Cellular development, cell death, cellular growth and proliferation | Cell cycle: G2/M DNA damage checkpoint regulation, p38 MAPK signaling |
mir-222 | Cellular development, reproductive system development and function, cell death | IGF-1 signaling, Axonal guidance signaling |