The l1-l2 regularization framework unmasks the hypoxia signature hidden in the transcriptome of a set of heterogeneous neuroblastoma cell lines

Table 1 NB cell lines used and the relative characteristics

Cell line		MYCN		Patient^a)		Tumor characteristics^a)
name	Morphology^b)	amplification	Expression^c)	Age^d)	sex	primary site	metastatic site^e)
ACN	neuroblast (N)	-	-	3.3	M	abdomen	BM, bone
SHEP-2	epithelial (S)	-	-	4	F	thorax	BM
GI-ME-N	neuroblast (N)	-	-	2	F	adrenal	LN, BM
SK-N-F1	epithelial (S)	-	-	11	M	unknown	BM
SK-N-SH	neuroblast/epithelial (I)	-	+	4	F	thorax	BM
SK-N-BE(2)c	neuroblast/epithelial (I)	+	+	2.2	M	unknown	BM
IMR-32	neuroblast (N)	+	+	1.1	M	abdomen	unknown
LAN-1	neuroblast (N)	+	+	2	M	unknown	BM, bone, LN
GI-LI-N	neuroblast (N)	+	+	1.11	F	adrenal	BM

^a)For references on specific items see [15]. ^b)N = neuroblastic; S = substrate adherant; I = intermediate. ^c)Measured by northern blotting. (-) = below detection; (+) = higly expressed (see materials and methods). ^d)Expressed as years.month. ^e)BM = bone marrow; LN = lymphnode

ISSN: 1471-2164