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Table 3 Out-of-sample validation

From: The l1-l2 regularization framework unmasks the hypoxia signature hidden in the transcriptome of a set of heterogeneous neuroblastoma cell lines

 

Cross validation

GSEA analysis

Cell type

errora)

NESb)

p-Valuec)

FDRd)

neuroblastoma

17%

1.89

<0.01

0

astrocyte

17%

1.60

<0.01

0.045

dendritic cell

33%

1.19

0.21

0.869

  1. a)Leave-one-out cross validation error estimated with regularized least squares. b)GSEA normalized enrichment score for the hypoxia signature gene set. c)Statistical significance of the enrichment score for the gene set. d)q-Value of the false discovery rate. Values < 0.25 are considered acceptable.
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BMC Genomics

ISSN: 1471-2164

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