Figure 1

The difference between robust and fragile transcriptional regulatory programs in TF co-activity. (A) We calculated pair-wise Pearson correlation coefficient in expression profiles between robust cooperative TFs or fragile cooperative TFs. Distributions of resulting correlation coefficient values are presented for robust cooperative TFs (green) and fragile cooperative TFs (red). Higher positive correlation indicates high co-activity (co-expressed). Robust cooperative TFs show higher co-activity than fragile cooperative TFs. (B) The binding and knockout overlap for all TFs and two subsets of TFs (see Materials and Methods). TFs that are more co-expressed (co-activity) with all other TFs have lower overlap, while TFs that are less co-expressed with all other TFs have greater overlap. Low overlap indicates robust transcriptional regulatory program.