Figure 7

Relationship between caloric restriction and aging. The association between CR and aging was evaluated for genes most strongly increased CR across tissues (Figure 2A), genes most strongly decreased by CR (Figure 2B), genes most strongly increased by aging (Figure 5A), and genes most strongly decreased by aging (Figure 5B). The "CR effect" is positive for genes up regulated by CR across tissues and negative for genes down regulated by CR across tissues. Likewise, the "age effect" is positive for genes up regulated with age across tissues and negative for genes down regulated with age across tissues. The magnitude of the CR effect and age effect reflects the degree of statistical significance. In particular, the CR effect is equal to I * -log[min(P _u , P _d )], where P _u and P _d are p-values generated by one-sided hypothesis tests of up and down regulation by CR across tissues, while I is equal to 1 if P _u <P _d and is equal to -1 otherwise. Similarly, the age effect is equal to I * -log[min(P _u , P _d )], where P _u and P _d are p-values generated by one-sided hypothesis tests of up and down regulation by aging, while I is equal to 1 if P _u < P _d and is equal to -1 otherwise.