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Table 1 miRNA target genes are less compact

From: Insight into microRNA regulation by analyzing the characteristics of their targets in humans

 

miRNA target genes

Non-miRNA target genes

Fold difference

Rank order

TargetScanS

n = 6444

n = 12428

  

Coding sequences length

2009 ± 26

(1512)

1575 ± 14

(1182)

1.28

1.28

6

3'UTR length

1730 ± 19

(1303)

1251 ± 11

(498)

1.38

2.62

1

5'UTR length

274 ± 3

(214)

197 ± 2

(131)

1.39

1.63

3

mRNA length

3989 ± 33

(3460)

2705 ± 19

(2161)

1.48

1.60

4

Total intron length

83699 ± 1890

(35802)

42275 ± 859

(14315)

1.98

2.50

2

Number of introns

11.6 ± 0.14

(9)

8.5 ± 0.01

(6)

1.37

1.50

5

PicTar

n = 6545

n = 12327

  

Coding sequences length

1771 ± 22

(1346)

1264 ± 13

(873)

1.40

1.54

4

3'UTR length

1688 ± 18

(1286)

965 ± 12

(497)

1.75

2.59

1

5'UTR length

271 ± 3

(214)

198 ± 2

(131)

1.37

1.63

3

mRNA length

3871 ± 32

(3363)

2757 ± 20

(2180)

1.40

1.54

4

Total intron length

80741 ± 1792

(33818)

43507 ± 910

(14564)

1.86

2.32

2

Number of introns

11.1 ± 0.14

(9)

8.5 ± 0.09

(6)

1.28

1.50

5

RNA22

n = 9055

n = 9817

  

Coding sequences length

1833 ± 20

(1398)

1622 ± 16

(1191)

1.13

1.17

5

3'UTR length

1415 ± 14

(976)

1032 ± 14

(499)

1.41

1.96

1

5'UTR length

231 ± 2

(171)

216 ± 3

(149)

1.07

1.15

6

mRNA length

3455 ± 26

(2898)

2856 ± 23

(2240)

1.21

1.29

4

Total intron length

61231 ± 1201

(25368)

51983 ± 1250

(14451)

1.18

1.76

2

Number of introns

11.6 ± 0.1

(8)

8.8 ± 0.1

(6)

1.32

1.33

3

  1. Comparison of the structure parameters of non-miRNA target genes with those of miRNA target genes predicted from TargetScans, PicTar, and RNA22. For each gene structure parameter the first line gives the average value ± s.e.m, and the 2nd line the median values in brackets. n: the number of genes in each category. The median lengths of miRNA target genes were significantly longer (one-side Wilcoxon rank sum test p < 10-250) than those of non-miRNA target genes in all parts of gene structures.