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Table 1 Differentially coexpressed modules

From: Dissecting the dynamics of dysregulation of cellular processes in mouse mammary gland tumor

module

size

cor_WT

p_WT

cor_h

p_h

cor_t

p_t

function

  

coexpressed

coexpressed

not coexpressed

 

35

27

0.33

0.02

0.13

0.02

0.02

0.33

cell adhesion

93

13

0.26

0.13

0.20

0.01

0.01

0.49

growth factor binding

  

coexpressed

not coexpressed

not coexpressed

 

51

19

0.35

0.01

0.01

0.47

0.02

0.44

metabolic processes

  

not coexpressed

coexpressed

coexpressed

 

5

92

0.05

0.37

0.04

0.05

0.01

0.09

acute immune response

40

25

0.00

0.8

0.07

0.05

0.10

0

integrin complex

54

18

0.06

0.68

0.08

0.11

0.05

0.14

immune response

131

11

0.18

0.32

0.09

0.14

0.10

0.08

ephrin receptor

  

not coexpressed

not coexpressed

coexpressed

 

14

40

0.07

0.51

0.01

0.36

0.05

0.03

respiratory chain

30

29

0.11

0.49

-0.03

0.98

0.05

0.06

signaling

65

16

0.16

0.9

0.05

0.42

0.11

0.11

nucleotide biosynthesis

69

15

0.02

0.76

-0.02

0.64

0.06

0.13

DNA repair

80

14

0.18

0.66

0.00

0.55

0.20

0.01

ER-Golgi transport

129

11

0.02

0.75

-0.06

0.72

0.09

0.13

hormone activity

  

coexpressed

not coexpressed

coexpressed

 

13

40

0.20

0.02

0.01

0.38

0.05

0.02

aminoacid metabolism

18

38

0.23

0.01

-0.01

0.6

0.10

0

energy metabolism

22

36

0.32

0.02

-0.03

0.91

0.09

0

ATPase

24

34

0.38

0.03

0.00

0.63

0.12

0

lysosome

33

28

0.50

0

0.01

0.34

0.03

0.11

protein transport

37

27

0.22

0.04

0.02

0.31

0.10

0.02

ribosome, DNA methylation

38

26

0.19

0.06

-0.02

0.74

0.11

0

chromatin

42

24

0.32

0

-0.01

0.54

0.06

0.03

tRNA synthetase

70

15

0.38

0.05

-0.06

0.95

0.07

0.1

protein degradation

83

14

0.42

0.04

-0.07

0.82

0.06

0.14

translation termination

  

not coexpressed

coexpressed

not coexpressed

 

74

15

0.11

0.72

0.18

0.07

0.02

0.59

Cu transporter

90

13

-0.06

0.96

0.15

0.08

-0.01

0.73

GABA receptor

102

12

-0.08

0.98

0.16

0.11

0.02

0.46

immune response

110

11

0.08

0.96

0.20

0.03

-0.06

1

coagulation

  1. Network modules whose coexpression differs between disease stages. Average value for Pearson's Correlation Coefficient in the module, and corresponding p-value in healthy (5 samples), hyperplastic (4 samples) and cancer samples (15) are shown (cor_WT, p_WT, cor_h, p_h, cor_t, and p_t, respectively). Significant coexpression was declared based on the p-value (threshold of p-value < 0.15: coexpressed; p-value > 0.3: not coexpressed).
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BMC Genomics

ISSN: 1471-2164

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