Comprehensive in silico prediction and analysis of chlamydial outer membrane proteins reflects evolution and life style of the Chlamydiae

Heinz, Eva; Tischler, Patrick; Rattei, Thomas; Myers, Garry; Wagner, Michael; Horn, Matthias

doi:10.1186/1471-2164-10-634

Table 2 Orthologous clusters of predicted chlamydial outer membrane proteins

From: Comprehensive in silico prediction and analysis of chlamydial outer membrane proteins reflects evolution and life style of the Chlamydiae

COMP cluster¹	C²	P²	o²	Description	No. of proteins	Int³	Lip³	Exp⁴
001	•	•	•	OppA - Oligopeptide binding proteins, ABC transporters	715		•
002	•	•	•	Amino acid binding proteins, ABC transporters	453		•
003	•	•	•	Amino acid binding proteins, ABC transporters	428		•
004		•	•	TolC - Type I secretion outer membrane proteins	364	•
005	•		•	PmpB/C - autotransporters/cell surface proteins	352	•		+
006		•	•	Spermidine/putrescine-binding proteins, ABC transporters	324		•
007	•	•	•	PmpG, PmpH - autotransporters/cell surface proteins	309	•		+
008	•	•	•	Metalloprotease, insulase family proteins; peptidase III proteins	297		•
009	•	•	•	Omp85 - outer membrane proteins, surface antigen (D15) proteins	294	•
010	•	•	•	Periplasmic solute binding proteins, ABC transporters	287	•		+
011	•	•	•	Pal - peptidoglycan-associated lipoproteins	279		•
012		•	•	Outer membrane proteins, multidrug efflux systems	274	•
013	•	•	•	ApbE - thiamine biosynthesis lipoproteins	265		•
014		•	•	Efflux transporter proteins, secretion proteins	258	•
015	•		•	Solute binding proteins, ABC transporters	234		•
016	•	•	•	TolB - translocation proteins	231		•
017	•	•	•	PmpG - autotransporters/cell surface proteins	225	•		+
018		•	•	ArcAB (MexAB) OprM - multidrug efflux pump outer membrane proteins	215		•
019	•	•	•	Mip - peptidyl-prolyl cis-trans isomerases	195	•
020	•	•	•	SctC - type three secretion system proteins	184	•		+
021		•	•	Omp85 - outer membrane proteins; surface antigen (D15) proteins	180	•
022		•	•	Outer membrane efflux proteins	163	•
023	•	•	•	GspD - general secretion pathway proteins	154		•
024		•	•	Wza - polysaccharide export proteins	143		•	+
025	•		•	PmpG - autotransporters/cell suface proteins	140	•
026		•	•	Fibronectin/fibrinogen binding proteins	127	•
027	•		•	Tarp - autotransporters/cell surface proteins	114	•		-
028	•	•	•	SctJ - type three secretion lipoproteins	104		•	-
029	•	•	•	Imp, OstA - organic solvent tolerance proteins	101	•
030	•	•	•	Skp, OmpH - outer membrane proteins	101	•
031		•	•	RhsB, RhsD - RHS family proteins	98	•
032	•		•	PmpB/C - autotransporters/cell surface proteins	94	•		+
033	•		•	DSBA-like thioredoxins, disulfide isomerases	92		•
034		•	•	Outer membrane efflux proteins	85		•
035	•		•	PmpD - autotransporters/cell surface proteins	85	•		+
036	•		•	Solute binding proteins, ABC transporters	73		•
037	•		•	PmpE/F - autotransporters/cell surface proteins	46	•		+
038		•	•	Host cell attachment-required proteins; most proteins hypotheticals	43	•
039		•	•	Flagellar hook associated proteins; outer membrane/cell surface proteins	43	•
040	•	•	•	ComL - competence lipoproteins	42		•
041		•	•	OsmY - osmotically inducible proteins	39		•
042	•		•	PmpG - autotransporters	38	•		+
043	•		•	Cell surface proteins	27	•	•	~
044	•	•	•	OmcB - 60 kDa cysteine-rich outer membrane protein	27	•		~
045	•		•	PmpA, PmpG - autotransporters/cell surface proteins	27	•		+
046	•		•	PmpE/F - autotransporters/cell surface antigens	25	•		+
047	•		•	Outer membrane proteins, most proteins hypotheticals	23	•
048	•	•	•	Cell wall associated proteins, most proteins hypotheticals	22	•
049	•	•	•	MORN motif proteins, kinases, most proteins hypotheticals	21	•	•
050	•	•	•	Hypothetical proteins	18	•
051	•		•	OprB - Carbohydrate-selective porins, most proteins hypotheticals	15	•		+
052	•		•	PmpG, PmiI - autotransporters/outer membrane proteins	15	•		+
053		•	•	Outer membrane proteins/invasins, most proteins hypotheticals	15	•
054	•		•	Flagellar hook proteins, most proteins hypotheticals	12	•
055	•		•	Hypothetical proteins	12	•
056	•		•	PmpG - autotransporters/cell surface proteins	12	•		+
057	•		•	Hypothetical proteins	11	•
058	•	•		Hypothetical proteins	11	•
059	•	•		Hypothetical proteins	11	•
060	•	•		Hypothetical proteins	11		•
061	•	•	•	CHLPN 76 kDa homologues	10	•		~
062	•	•		Hypothetical proteins	10		•
063	•		•	Hypothetical proteins	10		•
064	•			OmpA, MOMP - major outer membrane proteins	9	•		+
065	•			Hypothetical proteins	8		•
066	•			Hypothetical proteins	8		•
067	•	•	•	Hypothetical proteins	8		•
068	•		•	OmcA - 9 kDa cysteine-rich outer membrane proteins	8	•		-
069	•			Hypothetical proteins	7	•
070	•			Hypothetical proteins	7	•
071	•			Hypothetical proteins	7	•
072	•			Hypothetical proteins	7	•
073	•			Hypothetical proteins	7		•
074		•	•	OmpW - outer membrane proteins	7		•
075	•			OmpB, PorB - outer membrane proteins	7	•		+
076	•		•	PmpG, hypothetical proteins	7	•		+
077	•		•	Adherence factors, cytotoxins	6	•
078	•			Hypothetical proteins	6		•
079	•			Srp - 15 kDa cysteine-rich proteins	6	•		~
080	•			MAC/perforin family proteins	5	•
081		•		Hypothetical proteins	5	•	•
082	•			Hypothetical proteins	4		•
083		•		Hypothetical proteins	4	•
084		•	•	Hypothetical proteins	3		•
085		•		Hypothetical proteins	3		•
086	•			PmpE/F - polymorphic membrane proteins	3	•		+
087		•		Hypothetical proteins	2		•
088	•			PmpG - polymorphic membrane proteins	2	•		+

¹ Cluster number refers to pCOMP http://www.microbial-ecology.net/pcomp.
² Bullets indicate presence of proteins from Chlamydiaceae (C), Parachlamydiaceae (P) or other bacteria (other).
³ Cluster contains integral outer membrane proteins (Int) or outer membrane lipoproteins (Lip).
⁴ Experimental evidence available confirming (+) or contradicting (-) the prediction; ~, ambiguous reports about subcellular location

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ISSN: 1471-2164

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