Expression profiling and Ingenuity biological function analyses of interleukin-6- versus nerve growth factor-stimulated PC12 cells

Table 4 Top high-level functions identified by Ingenuity global function analysis of regulated genes in IL-6-versus NGF- stimulated PC 12 cells

Biological function classification	Number of genes	Significance (p-value)
IL-6-regulated genes
Cancer	61	2.98 × 10-6 to 5.16 × 10-3
Cellular Growth and Proliferation	54	1.14 × 10-6 to 5.16 × 10-3
Cell Death	47	4.54 × 10-6 to 5.16 × 10-3
Cell-to-Cell Signalling and Interaction	46	2.26 × 10-7 to 5.16 × 10-3
Tissue Development	45	2.26 × 10-7 to 5.15 × 10-3
Cellular Movement	39	9.19 × 10-6 to 5.16 × 10-3
Cellular Development	38	8.56 × 10-6 to 4.85 × 10-3
Small Molecule Biochemistry	37	1.32 × 10-5 to 4.47 × 10-3
...
Nervous system development and function	24	2.83 × 10-5 to 3.77 × 10-3
NGF-regulated genes
Cellular growth and proliferation	37	7.86 × 10-5 to 8.88 × 10-3
Cell-to-cell signalling and interaction	31	1.03 × 10-4 to 7.43 × 10-3
Molecular transport	30	8.89 × 10-6 to 8.70 × 10-3
Cancer	30	1.03 × 10-4 to 7.43 × 10-3
Cellular movement	29	2.41 × 10-5 to 8.70 × 10-3
Cell death	29	2.73 × 10-5 to 8.77 × 10-3
Neurological diseases	29	1.07 × 10-4 to 8.70 × 10-3
Nervous system development and function	29	1.60 × 10-4 to 8.70 × 10-3

ISSN: 1471-2164