Table 2 MD predicted receptor type selectivity of HAs compared with data from published experimental assays.
Tested HA variants | Simulation | in vitro | |||
|---|---|---|---|---|---|
α2,3 | α2,6 | α2,3 | α2,6 | Citation | |
Puerto-34 | +++* | +++ | NA | +++ | [16] |
Q222L Puerto-34 | +++* | ++ | NA | NA | - |
G224S Puerto-34 | +* | + | NA | NA | - |
Q222L/G224S Puerto-34 | +++* | +++ | NA | NA | - |
Sing-97 | +++ | ++ | +++ | + | [5] |
Q222L Sing-97 | ++ | ++ | ++ | ++ | [29] |
G224S Sing-97 | ++ | + | ++ | ++ | [29] |
Q222L/G224S Sing-97 | ++ | +++ | + | +++ | [29] |
Kan-1 | +++ | + | +++ | + | [19] |
L129V/A134V Kan-1 | +++ | +++ | +++ | +++ | [19] |