Table 1 Overall path statistics on pathways. The table shows the top-ranked pathways from the NCI PID database [12] when sorting paths by the maximum number of non-targeted paths that also contain siRNA genes after applying a filter to only include pathways with alternative paths that contain at least one HIV-1 target, at least one drug target and at least one si-RNA target.
From: Alternative paths in HIV-1 targeted human signal transduction pathways
Pathway Name | Number of end points | Number of paths | Non-targeted | Number of proteins | SiRNA | Group 1 | Group 2 | Predicted | Expert validated targets 1 | Expert validated targets 2 | Non-targeted + SiRNA genes | Number of drug targets |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Activated AMPK stimulates fatty acid oxidation in muscle | 6 | 17 | 16 | 5 | 1 | 1 | 1 | 1 | 0 | 0 | 4 | 2 |
1Generation of second Messenger molecules | 8 | 34 | 30 | 12 | 2 | 7 | 7 | 9 | 2 | 1 | 2 | 3 |
Phosphorylation of Emi1 | 3 | 10 | 8 | 4 | 1 | 1 | 2 | 2 | 0 | 0 | 2 | 1 |
Activation of BAD and translocation to mitochondria | 2 | 8 | 3 | 7 | 1 | 1 | 7 | 4 | 0 | 0 | 1 | 2 |
Mitotic Prometaphase | 2 | 4 | 2 | 78 | 12 | 4 | 5 | 10 | 1 | 0 | 1 | 1 |
Polo like kinase mediated events | 3 | 6 | 2 | 4 | 1 | 2 | 1 | 3 | 2 | 0 | 1 | 1 |
Notch HLH transcription | 2 | 11 | 5 | 3 | 1 | 2 | 1 | 3 | 0 | 0 | 1 | 1 |
Global Genomic NER GG NER | 10 | 13 | 9 | 20 | 5 | 10 | 7 | 13 | 1 | 0 | 1 | 1 |
Intrinsic Pathway | 2 | 4 | 4 | 17 | 2 | 4 | 2 | 5 | 0 | 0 | 0 | 10 |
Orc1 removal from Chromatin | 3 | 11 | 1 | 57 | 13 | 43 | 0 | 54 | 1 | 1 | 0 | 8 |
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2Cholesterol biosynthesis | 7 | 140 | 140 | 8 | 1 | 0 | 0 | 1 | 0 | 0 | 7 | 2 |
3EGFR downregulation | 12 | 88 | 5 | 17 | 4 | 6 | 4 | 11 | 3 | 1 | 0 | 4 |