Figure 2
From: Human liver rate-limiting enzymes influence metabolic flux via branch points and inhibitors
Characteristics of branch point metabolites in compound conversion network. (a) Compound conversion network in human liver. BPs represent branch points. RLs represent rate-limiting enzymes. The inhibitor BPs represent that the branch points are also enzyme inhibitors. The blue lines between pairs of nodes represent the conversion relation between them. (b, c, d) Boxplots are for degree, betweenness centrality and closeness centrality of branch points and all the metabolites in the compound conversion network. In each boxplot, the red bar represents the average degree, betweenness centrality and closeness centrality for 59 inhibitor branch points surrounded by rate-limiting enzymes; the orange bar represents the average degree, betweenness centrality and closeness centrality for all 128 branch points; the green bar represents the average degree, betweenness centrality and closeness centrality for all 164 inhibitors, and the blue bar represents the average degree, betweenness centrality and closeness centrality for all 644 compounds in the compound conversion network.