Figure 1

Overview of the PDbase system. PDbase contains four components: (a) statistics of the substantia nigra (SN) ESTs discovered from normal and PD patient tissues, (b) functional annotation of the SN ESTs showing alternative splicing events and the significant differences in expression between normal and PD SN, (c) integrated information containing genes and genetic variation related to Parkinson's disease from HGNC, UniProt, dbSNP, OMIM, HGMD, and GAD, (d) characteristics of the PD-related genes from microRNA elements, repeat elements, genes distribution on gene ontology, bio-pathways, and protein-protein interaction network.