Figure 3From: Escherichia coli infection induces distinct local and systemic transcriptome responses in the mammary glandHierarchical clustering of transcriptome profiles after experimental infection with E. coli. Tissues of udder quarters of five healthy untreated cows (c24h-1 to 5) were used to generate three replicates of expression profiles as controls for three separate comparisons. A: Replicate 1 (c124h-1 to 5) was compared to patterns of infected udder quarters 6 h after inoculation with E. coli 1303 (i6h-6 to 10). B: Replicate 2 (c224h-1 to 5) was compared to patterns of infected udder quarters 24 h after inoculation (i24h-1 to 5). C: Replicate 3 (c324h-1 to 5) was compared to patterns of noninfected quarters of infected cows 24 h after infection (n24h-1 to 5). Samples for n24h-1, 2, 3 and 5 were pooled from one mock inoculated and one untreated udder quarter, while n24h-4 was derived from tissue of a single untreated quarter. The degree of similarity of their expression patterns is shown as a heatmap of the distance matrix (red: more similar, blue: less similar). The trees depict the pair wise relations with branch lengths proportional to the degree of similarity.Back to article page