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Table 2 Over-represented ordered TFBS pairs and unordered TFBS triplets in LIVR, PLAC and THYM co-expression clusters.

From: Functional annotation of novel lineage-specific genes using co-expression and promoter analysis

Cluster

aTFBS singles and pairs

P-value

P-valuec

Ref.

CRSD pathway (<10-03) and

PREMOD identifierd

LIVR

Oct-1b

0.002

0.152

[37]

NAe

 

p53

0.002

0.152

[36]

NA

 

Sp1*Pax-8

0.001

0.049

[72]

Agrin in postsynaptic differentiation;

glycerophospholipid metabolism

 

SREBP-1*Pax-8b

0.002

0.049

[40]

glycerophospholipid metabolism;

Agrin in postsynaptic differentiation

 

ZF5*YY1

0.002

0.049

[73]

Wnt signaling pathway;

antisense pathway

 

Ebox*c-Ets-1(p54)

0.004

0.052

[74]

nicotinate and nicotinamide

metabolism; signal transduction

 

AP-2, ZF5, c-Ets

-1(p54)b

0.027

0.026

[43]

adipocytokine signaling pathway;

HIV-I Nef: negative effector of Fas

and TNF

PLAC

STAT*Pax-2b

0.0009

0.10

[75, 76]

glycerolipid metabolism (with STAT

family); prion pathway; mod027529

 

Tax/CREB*ETF

10-05

0.039

NA

EGFR-specific transcription factor

(ETF) not found in CRSD

 

Oct-1*GATA-4

0.0009

0.10

[77]

mod003360; mod065501; mod070287

 

Tel-2*VDR

0.0005

0.10

NA

Phosphatidylinositol signaling system;

mod100969

THYM

v-Mybb

10-05

0.069

[78]

NA

 

KROX

0.004

0.224

[79]

NA

 

Nkx2-5*CdxAb

0.0006

0.077

[54]

N-glycan biosynthesis; ribosome;

mod004754

 

MAF*HOXA7

0.0002

0.077

NA

phospholipase C-epsilon pathway

  1. a * indicates order in this composite; ',' within the TFBS composite indicates an unordered composite.
  2. b Indicates that this composite is also predicted in an LST.
  3. c FDR corrected P-value
  4. d mod#, PREMOD identifier representing a predicted TFBS module.
  5. e NA, not applicable.