Table 2 Characteristics of the putative SRO active sites.
Name | Identifier | WWE | Catalytic Core Motif | Loop length (between β 4 and β 5) | NAD binding | Predicted Activity | Confirmed Activity |
|---|---|---|---|---|---|---|---|
AtPARP1 | At4g02390.1 | No | H486 Y520 E614 | 38 | yes | PARP | PARP [44] |
AtPARP2 | At2g31320.1 | No | H833 Y867 E960 | 36 | yes | PARP | ND |
AtPARP3 | At5g22470.1 | No | C653 V687 E782 | 36 | yes | PARP | ND |
AtRCD1 | At1g32230.1 | Yes | L333 H365 N428 | 5 | no * | inactive | inactive * |
AtSRO1 | At2g35510.1 | Yes | V329 H361 N422 | 5 | ND | inactive | ND |
AtSRO2 | At1g23550.1 | Yes | Y118 H153 N216 | 5 | ND | inactive | ND |
AtSRO3 | At1g70440.1 | Yes | Y110 H145 K208 | 5 | ND | inactive | ND |
AtSRO4 | At3g47720.1 | Yes | C129 C150 K214 | 6 | ND | inctive | ND |
AtSRO5 | At5g62520.1 | Yes | C113 Y143 K207 | 5 | ND | inactive | ND |
HsPARP1 | P09874 | No | H862 Y896 E988 [24] | 37 | yes | PARP | PARP |
HsPARP7 | Q7Z3E1 | Yes | H532 Y564 I631 [26] | 6 | ND | mART | ND |
HsPARP10 | Q53GL7 | No | N886 Y919 I987 [26] | 6 | yes | mART | mART |
HsPARP11 | Q9NR21 | Yes | H197 Y229 I313 [26] | 6 | ND | mART | ND |
HsPARP12 | Q9H0J9 | Yes | H564 Y596 I660 [26] | 6 | ND | mART | ND |
HsPARP13 | Q7Z2W4 | Yes | Y787 Y819 V876 [26] | 6 | ND | inactive | inactive |
HsPARP14 | NP_060024 | Yes | H1682 Y1714 L1782 [26] | 6 | yes | mART | mART |