Figure 4

Proliferation signature in four transcriptional datasets. Genomics Portals were used to study the functional importance of 85 genes constituting in the rat mammary cell proliferation signature in five different biological processes examined in 4 gene expression datasets. A) The comparison of between the largest (top quartile) and smallest (bottom quartile) tumors with the assumption that large tumors are "more proliferative" than small tumors in the Miller dataset. B) The comparison between the proliferating and growth-arrested cell lines in the Fournier expression dataset. C) The comparison between all 13 different murine breast cancer models and normal controls in the Herschkowitz expression dataset. D) The transcriptional effects of estrogen on ER- breast cancer cell line after re-expression ESR1 in the Moggs expression dataset. E) The transcriptional effects of estrogen on ER- breast cancer cell line without re-expression ESR1 in the Moggs expression dataset.