Figure 5

Proliferation signature in transcription factor binding ChIP-seq data. Genomics Portals were used to examine the promoter binding events in the ChIP-seq dataset assessing DNA binding of 15 different transcription factors, including E2F1, in mouse embryonic stem cells. A) Binding patterns for all 15 transcription factors in the promoter regions (-4 kb to +1 kb around TSS) of the 85 genes constituting the rat mammary epithelium proliferation signature. B) n-Myc binding patterns in the promoters of a subset of the genes constituting the proliferation signature. This higher-resolution figure was generated by filtering-out other 14 transcription factors.