Figure 3

Modules of correlated transcripts associated with variation in body weight and energy metabolism traits. (A) Heat map of correlated probe sets after module formation for BW (13 modules), GLY (9 modules), TAG (5 modules), GLYC (13 modules), and MR (6 modules). Each point represents the correlation between two genes. The color scale bar indicates the value of the correlation. (B) Interaction network of correlated (|r| ≥ 0.7) transcripts for BW module 10. Each node represents a gene and each edge a significant correlation between a pair of genes. (C) Distribution of tissue-specific expression of transcripts in BW module 10 based on data from FlyAtlas http://www.flyatlas.org/[49]. (D) Interaction network of correlated (|r| ≥ 0.6) transcripts for GLY module 7. (E) Network of correlated (|r| ≥ 0.7) transcripts for TAG module 4. (F) Interaction network of correlated (|r| ≥ 0.9) transcripts for GLYC module 11. (G) Distribution of tissue-specific expression of all transcripts associated with MR. Nodes showed as pink in the interaction networks represent those candidate genes for which homozygous mutants were tested. The visualization of interaction networks was performed using Cytoscape 2.6.3. [84].