Functional and evolutionary correlates of gene constellations in the Drosophila melanogaster genome that deviate from the stereotypical gene architecture

Table 3 Multivariate model fitting of genomic- and functional properties^a of genes to their evolutionary properties^b.

Evolutionary property (sample size)	Genomic and functional properties	Fitted model	R	P-value
Codon usage bias (CAI) (N = 10118)	X- versus autosomal linkage (Chr.)	-0.027 + 0.256 Chr.	0.096	1.0 × 10^-6
	Gene Ontology (GO)	-0.077 + 0.256 Chr. + 0.123 GO	0.114	1.0 × 10^-6
	Recombination rate (Rec.) and gene constellation (Const.)	0.051 + 0.222 Chr. + 0.114 GO + 0.041 Rec. - 0.008 Const.	0.129	1.0 × 10^-6
Ka/Ks (N = 7425)	Gene Ontology (GO)	0.103 - 0.246 GO	0.121	1.0 × 10^-6
	Gene constellation (Const.)	-0.115 - 0.222 GO + 0.014 Const.	0.144	1.0 × 10^-6
Tajima's D (N = 461)	Recombination rate (Rec.)	0.239 - 0.301 Rec.	0.160	6.0 × 10^-4
	Gene Ontology (GO)	0.154 - 0.293 Rec. + 0.184 GO	0.184	4.0 × 10^-4
F_ST(N = 461)	X- versus autosomal linkage (Chr.)	-0.286 + 0.657 Chr.	0.326	1.0 × 10^-6
Q_ST(N = 3238)	No fitting model

^aSubset of properties chosen from Table 1 whose effects on the evolutionary dynamics of genes commonly appreciated
^bC.f. Table 2
^cKa and Ks analyzed separately (c.f. main text for results)
^dθ_W and θ_π analyzed separately (c.f. main text for results)

ISSN: 1471-2164