Table 2 Prediction of Sampling Scheme I
From: Inferring linkage disequilibrium from non-random samples†
Pop. | p | q | (D min , D max ) | D |
|
|
|---|---|---|---|---|---|---|
1 | 0.5 | 0.5 | (-0.25, 0.25) | 0.20 | 0.1999 ± 0.0078 | 0.2004 ± 0.0078 |
2 | 0.5 | 0.5 | (-0.25, 0.25) | 0.10 | 0.1002 ± 0.0145 | 0.1003 ± 0.0145 |
3 | 0.3 | 0.3 | (-0.09, 0.21) | 0.09 | 0.0898 ± 0.0133 | 0.0899 ± 0.0125 |
4 | 0.7 | 0.7 | (-0.09, 0.21) | 0.09 | 0.0895 ± 50.0133 | 0.0896 ± 0.0126 |
5 | 0.3 | 0.5 | (-0.15 0.15) | 0.10 | 0.0997 ± 0.0120 | 0.0998 ± 0.0111 |
6 | 0.5 | 0.3 | (-0.15, 0.15) | 0.10 | 0.0995 ± 0.0121 | 0.0993 ± 0.0109 |
7 | 0.5 | 0.5 | (-0.25, 0.25) | -0.20 | -0.1995 ± 0.0081 | -0.1998 ± 0.0081 |
8 | 0.5 | 0.5 | (-0.25, 0.25) | -0.10 | -0.0996 ± 0.0146 | -0.0997 ± 0.01460 |
9 | 0.3 | 0.3 | (-0.09, 0.21) | -0.09 | -0.0896 ± 0.0074 | -0.0899 ± 0.0068 |
10 | 0.7 | 0.7 | (-0.09, 0.21) | -0.09 | -0.0897 ± 0.0073 | -0.0899 ± 0.0065 |
11 | 0.3 | 0.5 | (-0.15 0.15) | -0.10 | -0.1000 ± 0.0124 | -0.1000 ± 0.0117 |
12 | 0.5 | 0.3 | (-0.15, 0.15) | -0.10 | -0.0995 ± 0.0120 | -0.0993 ± 0.0111 |
± s.d.
± s.d.- Linkage disequilibrium parameters were estimated based on 1000 simulations of n = 200 individuals from 12 different populations: p and q are the frequencies of alleles of the marker (M) and trait (A), D is the coefficient of linkage disequilibrium between the marker and the disease loci, D
min
and D
max
are respectively the minimum and maximum possible coefficients of linkage disequilibrium given allelic frequencies p and q,
and 
are the estimates from Methods H and L respectively, and the means and standard deviations, s.d., calculated from 1000 simulations.