Inferring linkage disequilibrium from non-random samples†

BMC Genomics

Table 5 Prediction from case-control samples with various sample sizes

p	q	D	n= 100	n= 200	n= 400	n= 800
± s.d.
0.6	0.005	-0.002	0.002 ± 0.001	-0.002 ± 0.002	-0.002 ± 0.000	-0.002 ± 0.000
0.5	0.010	0.004	0.004 ± 0.001	0.004 ± 0.001	0.004 ± 0.000	0.004 ± 0.000
0.5	0.020	0.008	0.008 ± 0.002	0.008 ± 0.001	0.008 ± 0.001	0.008 ± 0.001
0.3	0.030	0.010	0.010 ± 0.003	0.011 ± 0.002	0.010 ± 0.002	0.010 ± 0.001
0.7	0.040	0.010	0.010 ± 0.004	0.011 ± 0.002	0.010 ± 0.002	0.010 ± 0.001
0.3	0.050	0.020	0.021 ± 0.005	0.021 ± 0.004	0.021 ± 0.003	0.021 ± 0.002
0.5	0.100	0.040	0.044 ± 0.008	0.045 ± 0.006	0.046 ± 0.004	0.045 ± 0.003
LOD ± s.d.
0.6	0.005	-0.002	1.852 ± 1.047	3.619 ± 1.467	6.913 ± 2.112	13.774 ± 2.927
0.5	0.010	0.004	1.949 ± 1.036	3.692 ± 1.454	7.397 ± 1.959	14.390 ± 2.809
0.5	0.020	0.008	2.010 ± 1.045	3.843 ± 1.483	7.657 ± 2.070	14.955 ± 2.832
0.3	0.030	0.010	1.545 ± 1.047	2.957 ± 1.395	5.596 ± 1.977	11.085 ± 2.717
0.7	0.040	0.010	1.115 ± 0.707	2.093 ± 1.043	3.958 ± 1.377	7.682 ± 2.063
0.3	0.050	0.020	2.325 ± 1.278	4.393 ± 1.690	8.648 ± 2.452	17.191 ± 3.332
0.5	0.100	0.040	2.493 ± 1.100	4.860 ± 1.549	9.560 ± 2.165	18.948 ± 2.994

Means and standard deviations of the estimates of the disequilibrium coefficients and the corresponding LOD score from using various sizes of case-control samples.

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