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Table 3 TFAP2A binding site sequences present in the regulatory regions of some TFAP2A- modulated genes.

From: Identification of functional TFAP2A and SP1 binding sites in new TFAP2A-modulated genes

Gene Symbol

ENSEMBL ID

Microarray FC

TFAP2A binding sequence

TFAP2A binding score

Position

ESDN/DCBLD2

ENSG00000057019

5.7

GCCGCGGGG

12.74

-269

   

GCCCGCAGC

11.54

-10

PPARG

ENSG00000132170

2.6

GCCTGAGGC

11.48

-851

   

GCCGGGGGC

12.82

-280

   

GCCGCGGGG

12.74

-176

   

GCCCCGCGG

11.77

-175

   

GCCGTGGGC

11.94

-134

   

GCCCGGCGC

11.85

+10

   

GCCCGCGGC

12.85

+42

EREG

ENSG00000124882

2.5

CCCTCGGGC

12.75

-101

CXCL1

ENSG00000163739

2.4

GCCCGGGGG

13.46

-64

   

GCCCCCGGG

12.76

-63

   

GCCCGGAGC

12.14

-56

   

GCCGCAGGC

11.91

+13

CD59

ENSG00000085063

1.7

GCCCTGGGG

12.58

-336

   

GCCCCAGGG

12.55

-335

   

GCCGGGAGC

11.51

-37

   

GCCGGGGGG

12.83

+3

ADAMTS1

ENSG00000154734

1.7

GCCCGCAGC

11.54

-142

   

GCCGGGGGC

12.82

-107

SLIT2

ENSG00000145147

1.7

GCCGGGGGC

12.81

-679

   

GCCCCGAGG

12.06

-248

CASP9

ENSG00000132906

-1.5

GCCCTGGGG

12.58

-734

   

GCCCCCAGG

11.45

-463

   

GCCCCCAGG

11.45

-370

   

GCCCGCAGG

11.55

-182

   

GCCCTGGGG

12.58

+4

   

GCCCCCAGG

11.45

+69

   

GCCCCGCGC

11.75

+2

TGFBI

ENSG00000120708

-1.6

GCCCTGGGG

12.58

-899

   

GCCCCCAGC

11.44

-414

   

GCCCTGGGC

12.57

-212

   

GCCCTGGGC

12.57

+43

GLO1

ENSG00000124767

-2.0

GCCGCGGGC

12.72

-24

FASTK

ENSG00000164896

-2.2

GCCCGGAGG

12.15

-856

   

GCCCCGAGC

12.04

-500

   

GCCCGGGGC

13.45

-413

   

GCCCCGGGG

13.36

-393

   

GCCCCCGGG

12.76

-391

   

GCCCTCGGC

11.97

-66

   

GCCCGGCGC

11.85

-59

   

GCCCGCGGG

12.86

-42

   

GCCGGGAGC

11.51

-2

KRT16

ENSG00000186832

-2.5

GCCCTCGGG

11.98

-860

   

GCCCCCGGG

12.76

-650

   

GCCTGAGGC

11.48

-502

   

GCCCCGAGG

12.06

-279

   

GCCCTCGGG

11.98

-277

KRT17

ENSG00000186831

-2.7

GCCCCGGGG

13.36

-525

   

GCCCCGGGG

13.36

-524

   

GCCCCCAGC

11.44

-203

   

GCCTGGGGG

12.30

+56

PLCXD2

ENSG00000144824

-1.5

CCCCCTTGGC

9.47*

-878

   

GGCCAGGGC

9.04*

-64

IFI44

ENSG00000137965

-1.9

-

-

-

  1. For each ChIP-validated TFAP2A target gene or negative control (see figure 3 and 6) Gene Symbol, ENSEMBL IDs, TFAP2A binding site sequence, score and position (referring to the TSS as +1) are shown. ADAMTS1: ADAM metallopeptidase with thrombospondin type 1 motif, 1; CASP9: caspase 9; CD59: CD59 molecule, complement regulatory protein; CXCL1: chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity alpha); DCLBD2/ESDN: Endothelial and smooth muscle cell derived neuropiline like molecule; EREG: Epiregulin; FASTK: fast kinase; GLO1: glyoxalase I; KRT16: keratin 16; KRT17: keratin 17; IFI44: interferon-induced protein 44; PLCXD2: pleckstrin homology-like domain family B member 2; PPARG: peroxisome proliferator activated receptor gamma; SLIT2: slit homolog 2 (Drosophila); TGFBI: Transforming Growth Factor Beta-Induced. * low score binding sites, used as negative controls.
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BMC Genomics

ISSN: 1471-2164

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