The ubiquitin-conjugating enzyme HR6B is required for maintenance of X chromosome silencing in mouse spermatocytes and spermatids

Table 1 Overview of differential gene expression in Hr6b knockout spermatids versus wild type per chromosome.

Chrom	Chrom length	# genes	gene density	# differentially expressed	% differentially expressed	up in ko	down in ko	fraction up in ko
1	197195432	1272	155028	412	32.4	134	278	0.33
2	181748087	1942	93588	555	28.6	187	368	0.34
3	159599783	1071	149019	306	28.6	98	208	0.32
4	155630120	1410	110376	402	28.5	151	251	0.38
5	152537259	1339	113919	424	31.7	140	284	0.33
6	149517037	1149	130128	363	31.6	120	243	0.33
7	152524553	2026	75284	426	21.0	207	219	0.49
8	131738871	1121	117519	318	28.4	102	216	0.32
9	124076172	1289	96258	372	28.9	129	243	0.35
10	129993255	1042	124754	319	30.6	117	202	0.37
11	121843856	1748	69704	490	28.0	182	308	0.37
12	121257530	733	165426	270	36.8	63	207	0.23
13	120284312	882	136377	253	28.7	85	168	0.34
14	125194864	879	142429	251	28.6	79	172	0.31
15	103494974	835	123946	289	34.6	115	174	0.40
16	98319150	706	139262	244	34.6	78	166	0.32
17	95272651	1096	86928	285	26.0	125	160	0.44
18	90772031	528	171917	173	32.8	37	136	0.21
19	61342430	758	80927	239	31.5	89	150	0.37
x	166650296	965	172695	160	16.6	144	16	0.90
y	15902555	12	1325213	0	0
				Total A	Average A	Total A	Total A	Average A
				6391	30.1	2238	4153	0.35

*The first column shows the chromosome (chrom) number, followed by the length in bp, the number (#) of genes, the gene density, the number of differentially expressed genes, the percentage of differentially expressed genes, the number of upregulated genes in Hr6b knockout spermatids compared to wild type (up in ko), the number of downregulated genes in Hr6b knockout compared to wild type (down in ko), and the fraction of upregulated genes (fraction up in ko). The bottom row shows the total or average values for the columns as indicated for the autosomes only (A).

ISSN: 1471-2164