Figure 3
From: Causal reasoning identifies mechanisms of sensitivity for a novel AKT kinase inhibitor, GSK690693
Inhibition of MYC and consequent inhibition of TFRC. A) Upper Panels: Genes that are consistent with decreased transcriptional activity MYC are green, those inconsistent are red. Lower panels: Genes that are consistent with decreased transcriptional activity MYC are red, those inconsistent are green. B) Upper Panels: Genes that are consistent with decreased TFRC activity are green, those inconsistent are red. Lower panels: Genes that are consistent with decreased TFRC activity are red, those inconsistent are green. All panels: Genes that are not considered to be changed due to a non-significant fold change or p-value are white. Genes that are inconsistent with the predicted activity are represented in Additional file 2 Table S2 and Additional file 8 Table S5 with an "X".