Figure 4
From: Causal reasoning identifies mechanisms of sensitivity for a novel AKT kinase inhibitor, GSK690693
Regulation of cell cycle controllers is evidenced by changes in RNA expression levels. A) Upper Panels: Genes that are consistent with decreased transcriptional activity of E2f1are green, those inconsistent are red. Lower panels: Genes that are consistent with decreased transcriptional activity of E2f1 are red, those inconsistent are green. B) Upper Panels: Genes that are consistent with increased activity of CDKN1A are green, those inconsistent are red. Lower panels: Genes that are consistent with increased activity of CDKN1A are red, those inconsistent are green. C) Upper Panels: Genes that are consistent with increased transcriptional activity of RB1 are green, those inconsistent are red. Lower panels: Genes that are consistent with increased transcriptional activity of RB1 are red, those inconsistent are green. All panels: Genes that are not considered to be changed due to a non-significant fold change or p-value are white. Genes that are inconsistent with the predicted activity are represented in Additional files 10, 11 and 12 Tables S6-S8 with an "X".