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Table 2 Functional Classification of Gene Clusters

From: A systems approach to mapping transcriptional networks controlling surfactant homeostasis

BioProcess

Clusters

Carbohydrate/organic acid metabolism

23, 24

cell adhesion

1,3,23,24

cell cycle

14,15,16

cell differentiation

1,10

cell migration/motility

3

defense response

10,20,21,22

development

1,3,10,19,23,27,28

DNA metabolism/replication

14,15

localization/transport

1, 3, 10,28

lipid metabolism

1, 2, 23,28

metabolism

5,6,8,9,12,13,14,15,16,17,23,24,28

morphogenesis

1,23,24,27,28

negative regulation of biological process

13,23,24

Regulation (Transcription/signaling)

5,6,9,11,14,15,16,18, 19, 23, 24

protein modification

12

regulation of cell size

24

RNA splicing

7

cytoskeleton organization and biogenesis

19, 24

blood vessel development

3,19

  1. Clusters listed in Additional file 1 were subject to Gene Ontology analysis http://david.abcc.ncifcrf.gov/ to determine the extent of enrichment of biological function among genes in each cluster. Clusters sharing biological functions were grouped together according to the function. Shown in the table are enriched functional classes with enrichment p-value < 0.01 and shared by more than 20% of the genes in the cluster.