From: A systems approach to mapping transcriptional networks controlling surfactant homeostasis
Cluster name | Gene Number | Function and Process | Mouse Phenotype | Cell Components |
---|---|---|---|---|
C1 | 313 | Lipid biosynthesis; Morphogenesis; Differentiation; Proliferation; Lung and respiratory tube development; Vascular development | Abnormal vasculature development; Abnormal cardiovascular physiology; Abnormal alveolar morphology; Abnormal respiratory mechanics | Insoluble fraction; Membrane fraction |
C2 | 54 | Lipid Metabolism; Lipid Transport | Abnormal respiratory alveolar morphology; Abnormal lipid homeostasis | Endoplasmic reticulum |
C28 | 205 | Response to external stimulus; Lipid metabolic process | Abnormal blood chemistry | Insoluble fraction; Integral to plasma membrane |