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Table 3 Differentially expressed (DE) genes in the expression profile of 'Fully Resistant' animals 24 hours post-inoculation

From: Gene expression profiling in the lungs of pigs with different susceptibilities to Glässer's disease

Genes grouped by function

Genbank human RefSeq ID

FR v C fold change

FR v S fold change

More highly expressed in 'Fully Resistant' animals

   

Extracellular matrix components

   

Tenascin C ( TNC )

NM_002160

+2.30

+4.20

TGF-β-induced ( TGFBI )

NM_000358

+2.20

+4.69

Latent TGF-β binding protein 4 ( LTBP4 )

NM_003573

+2.07

+2.41

Collagen, type I, alpha 2 ( COL1A2 )

NM_000089

+2.03

+2.57

EGF-containing fibulin-like extracellular matrix protein 2 ( EFEMP2 )

NM_016938

+1.95

+2.01

Collagen, type III, alpha 1 ( COL3A1 )

NM_000090

+1.85

+2.43

Collagen, type XV, alpha 1 ( COL15A1 )

NM_001855

+1.84

+2.46

Collagen, type VI, alpha 3 ( COL6A3 )

NM_057167

+1.77

+2.33

Other

   

X (inactive)-specific transcript (XIST)

NR_001564

+2.89

+8.06

Slit homolog 3 (SLIT3)

NM_003062

+2.06

+2.57

Prolylcarboxypeptidase (PRCP)

NM_005040

+1.89

+2.60

Coiled-coil domain containing 80 (CCDC80)

NM_199512

+1.83

+2.43

Oligo SS00010557 (no significant hit to known gene)

NONE

+1.78

+3.36

Less highly expressed in 'Fully Resistant' animals

   

Retinoid-binding

   

Retinol binding protein 4 ( RBP4 )

NM_006744

-2.51

-6.54

Apolipoprotein D ( APOD )

NM_001647

-1.80

-2.43

Heat shock proteins

   

DnaJ, subfamily B, member 1 ( DNAJB1 )

NM_006145

-2.03

-3.51

Heat shock 70kDa protein 6 ( HSPA6 )

NM_002155

-2.20

-3.32

Lipid mobilization and metabolism

   

Lipoprotein Lipase (LPL)

NM_000237

-1.92

-5.05

Other

   

Oligo SS00011159 (no significant hit to known gene)

NONE

-1.77

-3.58

Transcobalamin I (TCN1)

NM_001062

-1.82

-4.63

DEAD box polypeptide 3, X-linked (DDX3X)

NM_001356

-2.22

-2.36

  1. A list of all genes that were differentially expressed in both the 'FR v C' and 'FR v S' comparisons 24 hours post-inoculation. Gene names were assigned on the basis of the best sequence match to a human gene identified by BLAST. Genes highlighted in bold are annotated with the 'GO' terms listed in the Results section. Genes not in bold type face were identified as having a particular function through literature searches. Genes are arranged in groups of related function. Fold changes are expressed with respect to the 'FR' animals. Gene expression is either higher (+) or lower (-) in 'FR' animals compared to 'Control' and 'Susceptible' animals (BH corrected p < 0.05).