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Table 4 Differentially expressed (DE) genes in the expression profile of 'Fully Resistant' animals 72 hours post-inoculation

From: Gene expression profiling in the lungs of pigs with different susceptibilities to Glässer's disease

Genes grouped by function

Genbank human RefSeq ID

FR v C fold change

FR v S fold change

More highly expressed in 'Fully Resistant' animals

   

Extracellular matrix components

   

Collagen, type I, alpha 1 ( COL1A1 )

NM_000088

+2.55

+3.94

Periostin ( POSTN )

NM_006475

+1.84

+3.16

Immunoglobulin

   

Immunoglobulin alpha heavy chain constant region (IGHA)

NONE

+2.03

+1.82

Retinoid-binding

   

Cellular retinoic acid binding protein 2 (CRABP2)

NM_001878

+1.97

+2.23

Other

   

Mortality factor 4 like 1 (MORF4L1)

NM_206839

+1.75

+2.64

Less highly expressed in 'Fully Resistant' animals

   

Retinoid binding

   

Apolipoprotein D ( APOD )

NM_001647

-2.04

-4.59

Retinol binding protein 4 ( RBP4 )

NM_006744

-2.36

-4.92

PPAR-γ regulators/regulated

   

Thioredoxin interacting protein (TXNIP)

NM_006472

-1.87

-2.43

Nuclear protein 1 (NUPR1)

NM_012385

-2.06

-1.75

Pyruvate dehydrogenase kinase, isoenzyme 4 (PDK4)

NM_002612

-2.33

-1.89

Lipid mobilization and metabolism

   

ATP-binding cassette, sub-family A, member 6 (ABCA6)

NM_172346

-2.69

-2.81

Other

   

Ubiquitin-conjugating enzyme E2L 6 (UBE2L6)

NM_004223

-1.78

+2.63

Annexin A8 like 2 (ANXA8L2)

NM_001630

-1.84

-2.73

Pre-mRNA cleavage complex II protein (PCF2)

NM_015885

-1.84

-3.27

Proprotein convertase subtilisin/kexin type 6 (PCSK6)

NM_138319

-1.85

-2.91

Glutathione S-transferase M3 (GSTM3)

NM_000849

-1.91

-1.99

BTG family, member 2 (BTG2)

NM_006763

-1.92

-2.85

Calnexin (CANX)

NM_001746

-2.30

-2.03

Thymosin like 3 (TMSL3)

NM_183049

-5.28

-4.86

Porcine endogenous retrovirus type C (PERV-C)

NONE

-7.11

-3.41

  1. A list of all DE genes identified in both the FR v C and FR v S comparisons 72 hours post-inoculation. Gene names were assigned on the basis of the best sequence match to a human gene identified by BLAST. Genes highlighted in bold are annotated with the 'GO' terms listed in the Results section. Genes not in bold type face were identified as having a particular function through literature searches. Genes are arranged in groups of related function. Fold changes are expressed with respect to the 'FR' animals. Gene expression was either higher (+) or lower (-) in 'FR' animals compared to 'Control' and 'Susceptible' animals (BH corrected p < 0.05).