Table 6 Selected genes that are more highly expressed in 'Susceptible' than 'Fully Resistant' and 'Control' animals at 72 hours post-inoculation
From: Gene expression profiling in the lungs of pigs with different susceptibilities to Glässer's disease
Genes grouped by function | Genbank human RefSeq ID | S v C fold change | S v FR fold change |
|---|---|---|---|
Pro-inflammatory cytokine/cytokine receptors | |||
S100 calcium binding protein A9 ( S100A9 ) | NM_002965 | +8.43 | +9.91 |
Interleukin 1 beta ( IL1B ) | NM_000576 | +5.65 | +4.01 |
S100 calcium binding protein A12 ( S100A12 ) | NM_005621 | +3.76 | +4.4 |
Chemokine (C-X-C motif) ligand 2 ( CXCL2 ) | NM_002089 | +2.45 | +2.32 |
Interleukin 8 ( IL8 ) | NM_000584 | +2.21 | +3.45 |
Anti-inflammatory cytokine/cytokine receptors | |||
CD163 antigen ( CD163 ) | NM_203416 | +2.71 | +2.49 |
Interleukin 1 receptor antagonist ( IL1RN ) | NM_173843 | +2.31 | +2.70 |
Interleukin 4 receptor (IL4R) | NM_000418 | +2.27 | +1.93 |
Neutrophil granule/phagocytosis proteins | |||
Cathelicidin antimicrobial peptide ( CAMP ) | NM_004345 | +5.30 | +10.41 |
Matrix metalloproteinase 9 (MMP9) | NM_004994 | +5.09 | +4.19 |
Transcobalamin I (TCN1) | NM_001062 | +4.48 | +4.10 |
Chitinase 3-like 1 (CHI3L1) | NM_001276 | +4.48 | +4.84 |
Solute carrier family 11 member A1 ( SLC11A1 ) | NM_000578 | +3.38 | +2.54 |
Cathepsin L (CTSL) | NM_145918 | +3.19 | +3.01 |
Neutrophil cytosolic factor 1 ( NCF1 ) | NM_000265 | +2.61 | +2.07 |
Cytochrome b-245, beta polypeptide ( CYBB ) | NM_000397 | +2.11 | +1.96 |
Ras-related C3 botulinum toxin substrate 1 ( RAC1 ) | NM_006908 | +2.07 | +1.86 |
Cathepsin C (CTSC) | NM_148170 | +2.07 | +2.29 |
Lipid mobilization and metabolism | |||
Resistin (RETN) | NM_020415 | +12.96 | +12.24 |
Adrenergic, alpha-2A-, receptor (ADRA2A) | NM_000681 | +3.71 | +3.85 |
Lipoprotein lipase ( LPL ) | NM_000237 | +3.70 | +4.54 |
Benzodiazapine receptor (peripheral) (BZRP) | NM_000714 | +2.55 | +3.10 |
Apolipoprotein D (APOD) | NM_001647 | +2.25 | +4.59 |
PDZK1 interacting protein 1 (PDZK1IP1) | NM_005764 | +2.15 | +2.48 |
Angiopoietin-like 4 (ANGPTL4) | NM_139314 | +2.14 | +3.07 |
Retinol binding protein 4 (RBP4) | NM_006744 | +2.10 | +4.94 |
Lipid biosynthesis | |||
Solute carrier family 2, member 3 (SLC2A3) | NM_006931 | +4.03 | +4.11 |
Leukotriene A4 hydrolase ( LTA4H ) | NM_000895 | +3.11 | +3.28 |
Thromboxane A synthase 1 ( TBXAS1 ) | NM_030984 | +2.24 | +1.97 |
Prostaglandin-endoperoxide synthase 1 ( PTGS1 ) | NM_080591 | +1.95 | +2.11 |
Arachidonate 5-lipoxygenase-activating protein ( ALOX5AP ) | NM_001629 | +1.94 | +2.35 |
Acyl-CoA synthetase long-chain family member 4 ( ACSL4 ) | NM_022977 | +2.07 | +2.06 |
1-acylglycerol-3-phosphate O-acyltransferase 6 ( AGPAT6 ) | NM_178819 | +2.31 | +2.52 |
Coagulation | |||
Thrombospondin 1 ( THBS1 ) | NM_003246 | +2.79 | +3.36 |
Serine proteinase inhibitor, clade E, member 1 ( SERPINE1 ) | NM_000602 | +2.49 | +2.55 |
Adaptor-related protein complex 3, delta 1 subunit (AP3D1) | NM_003938 | +2.24 | +2.28 |
Tumor necrosis factor, alpha-induced protein 6 (TNFAIP6) | NM_007115 | +2.63 | +2.90 |
Thromboxane A synthase 1 ( TBXAS1 ) | NM_030984 | +2.24 | +1.97 |
Phospholipid scramblase 4 ( PLSCR4 ) | NM_020353 | +2.02 | +2.86 |