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Table 6 Comparison of the power and proportion of false positives of KWII to RPM.

From: Comparison of information-theoretic to statistical methods for gene-gene interactions in the presence of genetic heterogeneity

K p

h 2

Model

α

Power %

RPM PFP*

    

KWII

RPM

 

0.3

0.62

5A

0.001

100

100

0.0010

   

0.0001

100

100

0.0002

 

0.3

5B

0.001

100

100

0.0018

   

0.0001

100

100

0.0004

 

0.15

5C

0.001

97.7

93.0

0.0014

   

0.0001

90.1

84.2

0.0003

0.1

0.22

6A

0.001

100

100

0.0011

   

0.0001

100

100

0.0002

 

0.11

6B

0.001

100

100

0.0014

   

0.0001

100

100

0.0004

 

0.056

6C

0.001

86.6

75.2

0.0013

   

0.0001

73.6

56.5

0.0002

0.01

0.02

7A

0.001

100

100

0.0010

   

0.0001

100

100

0.0002

 

0.01

7B

0.001

99.3

98.4

0.0013

   

0.0001

98.4

95.8

0.0003

 

0.005

7C

0.001

72.6

58.4

0.0016

   

0.0001

51.6

40.5

0.0005

  1. * α is calibrated to the empirical false positive rate of KWII
  2. The simulations are based on the models in [2].