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Figure 2 | BMC Genomics

Figure 2

From: Scoring of senescence signalling in multiple human tumour gene expression datasets, identification of a correlation between senescence score and drug toxicity in the NCI60 panel and a pro-inflammatory signature correlating with survival advantage in peritoneal mesothelioma

Figure 2

Senescence scoring of public data sets. Datasets tested were: irradiated and non-irradiated colorectal tumour and normal tissue (GSE15781); doxorubicin and 5-FU treated breast cancer cell lines (GSE1647); mesenchymal stem cells cultured to replicative senescence (GSE9593); a melanoma progression set (GSE4587). All sets were scored using (A) All markers from Table 1, (B) DAS markers, (C) mSS markers. Median senescence scores are shown with bars representative of the maximum and minimum values. In the case of the hMSC set, the time-course data are derived from the cells of a single donor without replication and therefore, no bars are shown.

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BMC Genomics

ISSN: 1471-2164

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