Figure 6

Signalling pathways linking genes whose expression profile clusters with the expression profile of GNAi2 (A) or APP (B). A. Genes resulting from the clustering analysis are in grey ellipses (HAND2: heart and neural crest derivatives expressed 2, DHDDS: dehydrodolichyl diphosphate synthase, COPS5: COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis), SLC2A5: solute carrier family 2 (facilitated glucose/fructose transporter), member 5, MAP3K12: mitogen-activated protein kinase kinase kinase 12) and intermediate molecules are in open ellipses (AGT: angiotensinogen (serpin peptidase inhibitor, clade A, member 8), ADAMTSL1: similar to ADAMTS-like protein 3 precursor (ADAMTSL-3) (Punctin-2), PARK2: parkinson disease (autosomal recessive, juvenile) 2, parkin, NPPA: natriuretic peptide precursor A, IFNG: interferon, gamma, RBL2 retinoblastoma-like 2 (p130), IL2: interleukin 2, TNF: tumor necrosis factor (TNF superfamily, member 2). B. Genes resulting from the clustering analysis are in grey ellipses (HSD17B4: hydroxysteroid (17-beta) dehydrogenase 4, DGKZ: diacylglycerol kinase, zeta 104 kDa, EN1: engrailed homeobox 1, PAPOLA: poly(A) polymerase alpha), PTP4A2: protein tyrosine phosphatase 4a2) and intermediate molecules are in open ellipses (CDK6: cyclin-dependent kinase 6, ALOX5: arachidonate 5-lipoxygenase, PRKCE: protein kinase C, epsilon, RAC1: ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) PRKCA: protein kinase C, alpha, GNRH1: gonadotropin-releasing hormone 1 (luteinizing-releasing hormone), ATF: activating transcription factor, CXCR4: chemokine (C-X-C motif) receptor 4, VCAM1: vascular cell adhesion molecule 1)