MicroRNA | Day 1 | Day 3 | Day 7 | Day 15 | Day 30 | Day 120 | Function |
---|---|---|---|---|---|---|---|
let-7b | Â | Â | Â | + | Â | Â | Ectopic expression of let-7b reduced HMGA2 expression and cell proliferation in a lung cancer cell line [33]. |
miR-106b | Â | Â | Â | + | Â | Â | miR-106b was up-regulated in several human tumors compared with adjacent normal tissues and formed a negative-feedback loop with cell cycle regulator E2F1 [43]. |
miR-130a | Â | Â | Â | + | Â | Â | Expression of miR-130a was significantly up-regulated in primary glioblastomas compared with normal peripheral brain tissue [44]. |
miR-130b | Â | Â | Â | + | Â | Â | miR-130b showed increased expression in patients with primary WHO grade II gliomas that spontaneously progressed to WHO grade IV secondary glioblastomas [45]. miR-130b was also up-regulated in human T-cell leukemia virus 1 (HTLV-1)-mediated cellular transformation [46]. |
miR-135b | Â | Â | Â | Â | + + | + + | miR-135b expressed was increased in patients with post-surgery elevation of prostate-specific antigen (chemical relapse), as compared with patients with non-relapse disease [47]. |
miR-138 | Â | Â | Â | + | Â | Â | miR-138 suppresses invasion and promotes apoptosis in head and neck squamous cell carcinoma cell lines [34]. |
miR-144 | Â | Â | Â | + | Â | Â | Introduction of miR-144 affected caspase activation in TRAIL-induced apoptosis pathway [48]. |
miR-150 | - | Â | Â | Â | Â | Â | Control of B cell differentiation by targeting the transcription factor c-Myb [49]. |
miR-219 | Â | Â | Â | + | Â | Â | miR-219 displayed dysregulated expression in human tongue carcinomas [50]. |
miR-222 | Â | Â | + | + | Â | Â | miR-222 was up-regulated in atypical teratoid-rhabdoid tumors [51]. |
miR-301a | Â | Â | Â | + | Â | Â | miR-301a expression was significantly differentiated in smoker versus non-smoker [52]. |
miR-302c* | Â | Â | - - - | - - - | Â | Â | ND |
miR-32 | Â | Â | Â | + | Â | Â | Over-expression of miR-32 was associated with poor outcome of human kidney cancer [53]. |
miR-335-5p | Â | Â | + | + | Â | Â | miR-335 was highly expressed in pediatric acute myeloid leukemia [54]. |
miR-337-5p | Â | Â | Â | + | Â | Â | ND |
miR-339-5p | Â | + | Â | Â | Â | Â | ND |
miR-34a | + | + + | + | + + + | + | Â | Regulation of p53-mediated apoptosis [32]. |
miR-34b-5p | + | + + | + + + | + + + | + + | Â | Induction of cell cycle arrest by joining p53 network [55]. |
miR-34c | Â | + | + + | + + | + | Â | Induction of cell cycle arrest by joining p53 network [35]. |
miR-369-5p | Â | Â | - - - | - - - | Â | Â | miR-369-5p was up-regulated in mesenchymal stem cells propagation [56]. |
miR-411 | Â | Â | - | Â | Â | Â | ND |
miR-423-5p | Â | + | Â | + | Â | Â | miR-423-5p was involved in muscle development and growth and showed greatest in the neonate development stage [57]. |
miR-434-5p | Â | Â | - | Â | Â | Â | ND |
miR-451 | Â | Â | Â | + | Â | Â | miR-451 expression was up-regulated in multidrug resistant cancer cell lines [58]. |
miR-453 | Â | Â | - | - | Â | + | A variant affecting miR-453's putative target site in estrogen receptor (ESR) 1 is associated with breast cancer risk in premenopausal women [59]. |
miR-466d-5p | Â | Â | Â | + + | Â | Â | ND |
miR-484 | Â | Â | Â | + | Â | Â | miR-484 was involved in adrenal tumorigenesis [60]. |
miR-487b | Â | Â | Â | + | Â | Â | ND |
miR-590-3p | Â | Â | + + + | Â | Â | Â | miR-590-3p and other miRNAs were suggested to mediate control of autoimmune gene expression [61]. |
miR-590-5p | Â | Â | Â | Â | + | Â | miR-590 was involved in regulating the expression of transforming growth factor TGF-beta1 and its receptor TGF-betaRII [62]. |
miR-672 | Â | Â | + + | + | Â | Â | ND |
miR-677 | Â | Â | + | + | Â | Â | ND |
miR-700 | Â | Â | Â | + | Â | Â | ND |
miR-707 | Â | Â | Â | + | Â | Â | ND |
miR-762 | Â | Â | Â | + | Â | Â | miR-762 was up-regulated in tumor tissue induced by DMBA [10]. |
miR-871 | Â | Â | Â | - | Â | Â | ND |
miR-875-3p | Â | Â | - - - | Â | Â | Â | ND |
miR-877 | Â | Â | Â | + | Â | Â | ND |
miR-883a-5p | Â | Â | Â | - | Â | Â | ND |
miR-93 | Â | Â | Â | + | Â | Â | miR-93 was over-expressed in human T-cell leukemia virus 1- transformed human T-cell lines and primary peripheral blood mononuclear cells from adult T-cell leukemia patients [46]. |
miR-681 | Â | Â | Â | Â | Â | + | ND |
miR-205 | Â | Â | Â | Â | Â | + | miR-205 expression was down-regulated in breast cancer, but up-regulated in other types of cancer including lung cancer, bladder cancer and ovarian cancer [63]. |
miR-142-3p | Â | Â | Â | Â | Â | + | miR-142-3p was over-expressed in childhood B-cell precursor acute lymphoblastic leukemia [64]. |