Integrated genomics of susceptibility to alkylator-induced leukemia in mice

BMC Genomics

Table 1 Functional enrichment of differentially expressed genes

Annotation	Annotation name	Count	P-Value (nominal)	Fold Enrichment	FDR (%)
GO:0008632	apoptotic program	11	9.58E-05	4.71	0.17
GO:0006464	protein modification process	88	1.77E-04	1.46	0.31
GO:0019318	hexose metabolic process	15	0.00107053	2.76	1.88
GO:0005996	monosaccharide metabolic process	15	0.00129867	2.71	2.28
GO:0046907	intracellular transport	43	0.00182315	1.63	3.18
mmu00240	Pyrimidine metabolism	11	0.00325706	2.98	3.99
GO:0031324	negative regulation of cellular metabolic process	25	0.00230736	1.95	4.01
GO:0009117	nucleotide metabolic process	18	0.00246768	2.27	4.29
GO:0009142	nucleoside triphosphate biosynthetic process	9	0.00286827	3.68	4.96
GO:0045934	negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	22	0.00335044	2.00	5.78
GO:0006915	apoptosis	39	0.00643571	1.56	10.81
mmu05210	Colorectal cancer	10	0.00953927	2.74	11.28
GO:0008637	apoptotic mitochondrial changes	5	0.00751505	6.23	12.52
GO:0006396	RNA processing	25	0.00852521	1.76	14.08
GO:0009064	glutamine family amino acid metabolic process	6	0.00927287	4.57	15.22
GO:0015031	protein transport	39	0.01063622	1.51	17.27
GO:0019362	pyridine nucleotide metabolic process	5	0.01370052	5.27	21.69
GO:0008219	cell death	39	0.01444197	1.48	22.73
GO:0016481	negative regulation of transcription	19	0.01461908	1.85	22.98

Count: Number of genes differentially expressed between t-AML-resistant and -susceptible inbred strains of mice with given annotation.

ISSN: 1471-2164